Space and Equipment Commitments: The Departments of Computer Science and Medicine will provide the necessary office space as well as most of the software and hardware computer equipment. The basic CHAIMS software infrastructure exists already; the same is true for most of the software for genomics computation. Our two research groups have currently over 50 workstations of various types and manufacture. We have a network that provides very high bandwidth interaction within the groups and high bandwidth among computer-science and medical information science. Staff for system maintenance is available. Necessary purchases covered by the award will mainly concern additional licenses for middleware systems like CORBA. We are often able to obtain hardware and software licenses at a substantial discount.