Inconsistency causes errors,while results need precision

False positives = poor precision

typically cost more than

false negatives = poor recall

Example: [ Todd Lowe tRNA search <rna.wustl.edu/tRDB > ]

Search in Yeast for 55 methylation sites

-- required manual elimination of pseudogenes

Search space in human genome is 215 times larger, not yet done

In drug-discovery we have now more targets than . pharmaceutical companies can afford to investigate

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